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We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
Our findings showed that vitamin C can prevent the activation of a protein called NF-kB, which is crucial for the inflammatory response. It turns out that vitamin C not only reduces the DNA-binding activity of NF-kB but also decreases the expression of TF and FSAP, suggesting it can effectively modulate clots formed in response to inflammation. Overall, we observed that vitamin C offers promising benefits in altering pro-inflammatory and pro-coagulation processes.
This means that aside from being a potent antioxidant, vitamin C might also support cardiovascular health by reducing the risk factors associated with clot formation during inflammatory responses. While more research is needed to validate these effects fully, our study opens the door to the potential role of vitamin C in managing clot-related disorders linked to inflammation.
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The results showed that vitamin C, when paired with fibrin clot, significantly improved tendon healing. Not only did it enhance the mechanical strength of the tendon, but it also led to better histological and biochemical outcomes, suggesting a more robust healing process. We noted increased levels of important growth factors in the groups treated with fibrin clot and vitamin C.
Importantly, the findings indicated that vitamin C plays a beneficial role in recovery, especially when combined with other treatment strategies. While further research may be necessary to fully understand its isolated effects, the data suggests that vitamin C is a valuable component in the healing bundle for Achilles tendon injuries.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
Our findings showed that vitamin C can prevent the activation of a protein called NF-kB, which is crucial for the inflammatory response. It turns out that vitamin C not only reduces the DNA-binding activity of NF-kB but also decreases the expression of TF and FSAP, suggesting it can effectively modulate clots formed in response to inflammation. Overall, we observed that vitamin C offers promising benefits in altering pro-inflammatory and pro-coagulation processes.
This means that aside from being a potent antioxidant, vitamin C might also support cardiovascular health by reducing the risk factors associated with clot formation during inflammatory responses. While more research is needed to validate these effects fully, our study opens the door to the potential role of vitamin C in managing clot-related disorders linked to inflammation.
After evaluating 739 patients, 296 were matched for a fair comparison. Notably, the findings suggest that while there was no significant reduction in mortality rates for those receiving vitamin C compared to those who did not, the use of vitamin C was linked to a lower occurrence of thrombosis—an abnormal blood clotting condition. The incidence of thrombosis in the vitamin C group was 6.1%, compared to 13% in the non-vitamin C group, indicating a possible protective effect against blood clots.
Ultimately, while the addition of vitamin C did not show a direct mortality benefit, it may offer some hope for reducing blood clot complications in these severely affected patients. However, further research will be necessary to validate these findings and clarify the role of vitamin C in treatment protocols for COVID-19.
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Frequently Asked Questions
A blood clot is a mass of blood that changes from a liquid to a gel, effectively forming a plug that can stop bleeding. This natural process, known as coagulation, is critical for preventing excessive blood loss when you sustain an injury. Blood clots can occur in various areas of the body, typically at the site of a wound, but they can also form within blood vessels without an obvious injury, which may lead to serious health complications.
While blood clots are essential for healing, they can pose significant health risks if they form inappropriately. For example, a deep vein thrombosis (DVT) occurs when a clot forms in a deep vein, usually in the legs, and can travel to the lungs, causing a life-threatening condition called a pulmonary embolism. Risk factors for blood clots include prolonged immobility, certain medical conditions, and the use of specific medications, among others. It’s important to recognize the symptoms of abnormal clotting, such as swelling, pain, and redness in the affected area, and seek medical attention if they occur.
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that plays a critical role in numerous bodily functions. As an essential nutrient, it contributes to the growth and repair of tissues in the body, and it is vital for the production of collagen, an important protein that helps maintain skin, cartilage, tendons, ligaments, and blood vessels. Additionally, Vitamin C acts as a powerful antioxidant, which means it helps combat free radicals—unstable molecules that can cause oxidative stress and contribute to various chronic diseases.
Moreover, Vitamin C enhances iron absorption from plant-based foods, making it a vital component for those following vegetarian or vegan diets. While many people get sufficient Vitamin C from a well-balanced diet that includes fruits and vegetables like oranges, strawberries, kiwi, broccoli, and bell peppers, some individuals might require supplementation. It's generally recommended to stay within the daily intake guidelines, as excessive consumption can lead to gastrointestinal disturbances. Overall, Vitamin C is not just a skincare celebrity—it's a fundamental part of maintaining overall health and well-being.
Vitamin C is renowned for its immune-boosting properties and its role as a powerful antioxidant, but its effects on blood clotting are somewhat nuanced. While vitamin C is essential for overall health and the maintenance of healthy blood vessels, there's limited direct evidence to suggest that it aids in the prevention or treatment of blood clots. Some studies indicate that vitamin C may contribute to healthier circulation and could potentially reduce the risk of conditions associated with blood clotting, such as cardiovascular diseases.
However, relying solely on vitamin C for managing or preventing blood clots is not recommended. It is always best to consult a healthcare professional before making any changes to your diet or supplementation routine, especially if you are at risk for blood clots or have existing health concerns. While vitamin C can play a role in overall vascular health, it should be part of a holistic approach that includes a balanced diet, regular exercise, and, if necessary, medical treatment.
Based on user reviews, the time it typically takes to see results from taking vitamin C for blood clot-related issues can vary significantly among individuals. Some users have noticed improvements in their symptoms within a few weeks. For instance, one user reported a reduction in nosebleeds and other benefits after just starting their regimen with one capsule daily ((Read Review)). Others, however, mentioned a more extended timeline for noticeable effects. One reviewer stated that after two years of trying various supplements, only the use of vitamin C allowed them to discontinue their blood pressure medication, indicating a longer period before experiencing significant benefits ((Read Review)).
In general, it's common for users to take this supplement consistently over a few months to fully appreciate its benefits, especially for collagen formation and issues related to blood vessels (Read Review). Overall, while many report positive changes relatively quickly, patience may be necessary for some individuals to achieve optimal results.
Vitamin C has shown some interesting potential concerning blood clotting, particularly in specific contexts. Research indicates that vitamin C supplementation may help reduce the incidence of thrombosis, especially in critically ill patients, like those suffering from COVID-19. In a study involving 739 patients, those receiving vitamin C exhibited a lower occurrence of thrombosis compared to those who did not receive the supplement, suggesting a protective effect against abnormal blood clotting [2]. Similarly, another study found that vitamin C could enhance clot rigidity and reduce fibrinolysis during living donor liver transplantation, potentially aiding in better outcomes for patients undergoing such complex procedures [4].
However, it's essential to note that the relationship between vitamin C and blood clotting isn't universally beneficial. High doses of vitamin C may pose risks, particularly in cancer patients, where it has been found to increase the likelihood of red blood cells becoming procoagulant, thereby raising the potential for blood clots [6]. Furthermore, while some studies suggest vitamin C can modulate clot formation in inflammatory contexts, more comprehensive research is needed to fully understand its effects [5]. In summary, vitamin C could offer some benefits for blood clot-related conditions, but its use should be approached with caution, especially regarding dosage and individual patient circumstances.
Users have reported a variety of improvements related to their symptoms after taking vitamin C. Many appreciate its benefits for collagen formation, which is linked to enhanced skin health and reduced inflammation. For example, one user noted that their facial inflammation subsided, and their mother experienced a cessation of leg pain after starting vitamin C, while others have observed accelerated healing of wounds and bruises ((Read Review)). Additionally, several users have highlighted improvements in their blood vessel health, with one stating they felt significantly less fatigued and noticed clear benefits over the course of a year (Read Review).
Moreover, individual experiences vary widely; one user was able to stop their blood pressure medication after a two-year struggle with other supplements, attributing their success to vitamin C (Read Review). Others have also expressed that they benefit from reduced bleeding, such as from gums (Read Review). Overall, these anecdotal accounts suggest that while many users may experience notable improvements, results can vary significantly, emphasizing the importance of individual body responses.
Based on user reviews, many individuals reported positive outcomes when combining vitamin C with other supplements for managing blood clot-related issues. Notably, some users specifically mentioned the inclusion of rutin, an ingredient beneficial for blood vessels, enhancing the effects of vitamin C. One user highlighted that their choice was influenced by its inclusion of rutin, which they found crucial for various bodily processes ((Read Review)). Another reviewer noted that the combination of vitamin C and rutin was particularly effective for individuals with specific concerns, such as rosacea, indicating a broader application for vascular health, especially in supplement mixtures ((Read Review)).
Additionally, users frequently mentioned that vitamin C seemed to work synergistically with their routines. For instance, one user took a substantial dosage of vitamin C daily and experienced reduced gum bleeding alongside other positive effects, suggesting that high doses in conjunction with other vitamins might provide compounded benefits for vascular health and potentially blood clot concerns ((Read Review)). Overall, the anecdotal evidence indicates that combining vitamin C with other targeted supplements, such as rutin, may enhance their effectiveness for managing blood vessel health and addressing blood clot-related issues.
Users have reported a variety of doses for Vitamin C in relation to treating blood clots and supporting vascular health. For instance, one user indicated taking around six pills a day, distributed throughout meals, which they felt significantly improved their blood vessel health over the year (Read Review). Another review highlighted the efficacy of a single daily capsule of 1000 mg, which reportedly helped alleviate leg pain and support blood vessel strength (Read Review).
Additionally, some users mentioned even higher doses, such as ten tablets a day, which not only contributed to improved gum health but also seemed beneficial for their overall vascular condition (Read Review). Overall, while individual responses to Vitamin C supplementation can vary, it appears that users typically observed positive effects at doses ranging from one to ten capsules or tablets per day. As always, it's crucial to consult with a healthcare professional before starting any new supplement regimen.
After evaluating 739 patients, 296 were matched for a fair comparison. Notably, the findings suggest that while there was no significant reduction in mortality rates for those receiving vitamin C compared to those who did not, the use of vitamin C was linked to a lower occurrence of thrombosis—an abnormal blood clotting condition. The incidence of thrombosis in the vitamin C group was 6.1%, compared to 13% in the non-vitamin C group, indicating a possible protective effect against blood clots.
Ultimately, while the addition of vitamin C did not show a direct mortality benefit, it may offer some hope for reducing blood clot complications in these severely affected patients. However, further research will be necessary to validate these findings and clarify the role of vitamin C in treatment protocols for COVID-19.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
The molecular changes in RBCs were attributed to oxidative stress induced by high vitamin C levels, disrupting important calcium and thiol balance in the cells. Furthermore, our findings showed that administering vitamin C at 0.5 to 1.0 g/kg in rats resulted in a significant increase in thrombosis events. More importantly, RBCs from cancer patients displayed an increased sensitivity to these prothrombotic effects compared to healthy individuals.
Given these observations, it’s crucial to approach high-dose vitamin C therapy with caution, particularly in patients already at a higher risk for blood clotting. While vitamin C is often thought to have health benefits, our study reveals a potential risk that must not be overlooked.
Our findings showed that vitamin C can prevent the activation of a protein called NF-kB, which is crucial for the inflammatory response. It turns out that vitamin C not only reduces the DNA-binding activity of NF-kB but also decreases the expression of TF and FSAP, suggesting it can effectively modulate clots formed in response to inflammation. Overall, we observed that vitamin C offers promising benefits in altering pro-inflammatory and pro-coagulation processes.
This means that aside from being a potent antioxidant, vitamin C might also support cardiovascular health by reducing the risk factors associated with clot formation during inflammatory responses. While more research is needed to validate these effects fully, our study opens the door to the potential role of vitamin C in managing clot-related disorders linked to inflammation.
References
- de Boer HC, Sawhney JS. Pediatric scurvy case report: a novel presentation with deep vein thrombosis secondary to large bilateral spontaneous iliac subperiosteal hematomas. BMC Pediatr. 2024;24:126. doi:10.1186/s12887-024-04579-4
- Al Sulaiman K, Aljuhani O, Saleh KB, Badreldin HA, Al Harthi A, et al. Ascorbic acid as an adjunctive therapy in critically ill patients with COVID-19: a propensity score matched study. Sci Rep. 2021;11:17648. doi:10.1038/s41598-021-96703-y
- Çelik M, Bayrak A, Duramaz A, Başaran SH, Kızılkaya C, et al. The effect of fibrin clot and C vitamin on the surgical treatment of Achilles tendon injury in the rat model✰. Foot Ankle Surg. 2021;27:681. doi:10.1016/j.fas.2020.09.006
- Kwon JH, Kim D, Cho H, Shin BS. Ascorbic acid improves thrombotic function of platelets during living donor liver transplantation by modulating the function of the E3 ubiquitin ligases c-Cbl and Cbl-b. J Int Med Res. 2019;47:1856. doi:10.1177/0300060518817408
- Parahuleva MS, Jung J, Burgazli M, Erdogan A, Parviz B, et al. Vitamin C suppresses lipopolysaccharide-induced procoagulant response of human monocyte-derived macrophages. Eur Rev Med Pharmacol Sci. 2016;20:2174.
- Kim K, Bae ON, Koh SH, Kang S, Lim KM, et al. High-Dose Vitamin C Injection to Cancer Patients May Promote Thrombosis Through Procoagulant Activation of Erythrocytes. Toxicol Sci. 2015;147:350. doi:10.1093/toxsci/kfv133
